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Symbol Name ID |
Tbx21
T-box 21 MGI:1888984 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Asthma |
Aspirin-induced asthma |
| Disease(s) Associated with TBX21 | ||
| asthma, nasal polyps, and aspirin intolerance |
| Mouse Phenotypes | immune system phenotype |
abnormal leukocyte migration |
increased susceptibility to induced colitis |
abnormal NK cell differentiation |
abnormal CD4-positive T cell differentiation |
abnormal T-helper 1 cell differentiation |
decreased NK cell number |
increased NK cell number |
decreased T helper 1 cell number |
increased T-helper 2 cell number |
decreased CD4-positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased NK T cell number |
absent NK T cells |
decreased memory T cell number |
abnormal T-helper 1 cell morphology |
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology |
abnormal immunoglobulin level |
increased IgM level |
abnormal NK cell physiology |
impaired natural killer cell mediated cytotoxicity |
increased natural killer cell mediated cytotoxicity |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal cytokine level |
abnormal interleukin level |
abnormal tumor necrosis factor level |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
increased interleukin-17 secretion |
increased interleukin-2 secretion |
increased tumor necrosis factor secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
CNS inflammation |
respiratory system inflammation |
increased susceptibility to parasitic infection |
increased susceptibility to Riboviria infection |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Tbx21duane/Tbx21duane | |||||||||||||||||||||||||||||||||||||||
| Tbx21m1Btlr/Tbx21m1Btlr | |||||||||||||||||||||||||||||||||||||||
| Tbx21tm1Glm/Tbx21tm1Glm | |||||||||||||||||||||||||||||||||||||||
| Tbx21tm1Srnr/Tbx21tm1Srnr | |||||||||||||||||||||||||||||||||||||||
| Tbx21tm1Glm/Tbx21+ | |||||||||||||||||||||||||||||||||||||||
| Tbx21tm1Srnr/Tbx21+ | |||||||||||||||||||||||||||||||||||||||
| Tbx21tm2Srnr/Tbx21tm2Srnr Tg(Cd4-cre)1Cwi/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||
| Tbx21tm2Srnr/Tbx21+ Tg(Cd4-cre)1Cwi/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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